Description

Iron in the liver may be present as ferritin or hemosiderin. Significant amounts of iron in the liver may be termed siderosis or hemosiderosis.


Iron stains: Prussian blue (Perl's, Gomori's)

 

Use of an iron stain:

(1) to identify brown cytoplasmic pigment

(2) to consider a disorder of iron storage

 

Parameters that may reported:

(1) intensity of staining

(2) focal vs diffuse

(3) cells affected (hepatocellular, Kupffer cells)

(4) anatomical zone (periportal, lobular, centrilobular)

 

Intensity scales may range from 0 to 3 or 4.

 

Staining

Scale

negative

0

minimal

1

mild

2

moderate

3

severe

4

 


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