Vasoactive substances (papaverine with phentolamine and/or PGE1) may be injected alone, or combined with other therapies such as use of a vacuum device.
Contraindications for testing by intracavernosal vasoactive injection:
(1) severe decompensated cardiovascular insufficiency
(2) critical coronary artery disease
(3) severe disturbances of liver function (papaverine)
(4) glaucoma (papaverine)
(5) severe benign prostatic hypertrophy with increased residual urine (papaverine)
Criteria for selection of patients for autoinjection with vasoactive agents:
(1) cooperative and reliable
(2) adequate followup
(3) trained in handling possible side effects
Contraindications for autoinjection therapy with vasoactive agents:
(1) decompensated cardiac and circulatory insufficiency
(2) intellectual incompetence
(3) lack of compliance
(4) severe psychiatric disorder
(5) sexual deviation
