Secondary Sclerosing Cholangitis (SSC) may occur following a major burn injury. This condition overlaps with SSC seen in critically-ill patients (SSC-CIP).
Features of post-burn SSC:
(1) no previous history of liver or biliary disease
(2) severe burn with severe arterial hypotension and/or hypoxemia
(3) development afterwards of cholestatic syndrome with abnormal liver function tests
(4) presence of multifocal strictures and dilatations of the intrahepatic bile ducts seen on imaging studies
(5) variable formation of intrahepatic biliary casts
(6) variable recurrent bacterial cholangitis
(7) no other better explanations for SSC
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