Most of cases of lymphedema occur as a result of one or more processed damaging lymphatic channels and/or lymph nodes.


Causes of damage to lymph nodes:

(1) regional lymph node dissection

(2) malignant lymphoma

(3) metastatic carcinoma

(4) necrotizing lymphadenitis

(5) radiation-induced fibrosis


Causes of damage to lymphatic channels:

(1) surgery

(2) trauma

(3) radiation-induced fibrosis

(4) neoplasm compressing or infiltrating lymphatic channels

(5) recurrent infection (erysipelas, cellulitis)

(6) chronic filariasis

(7) rheumatoid or psoriatic arthritis


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