The second-line Age-Adjusted International Prognostic Index (sAAIPI) is determined in patients with relapsed or primary refractory non-Hodgkin's lymphoma prior to second-line therapy. This is based on the age-adjusted IPI which is determined at the time of initial diagnosis.
Patient selection: relapsed or primary refractory non-Hodgkin's lymphoma
Parameters:
(1) serum LDH
(2) clinical stage
(3) Karnofsky Performance Status (KPS)
Parameter
Finding
Points
serum LDH
<= upper limit of normal
0
> upper limit of normal
1
clinical stage
stage I or II
0
III or IV
1
KPS
>= 80%
0
< 80%
1
sAAIPI =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 3
• The higher the score the worse the outcome and the response to second-line therapy.
sAAIPI
Risk Group
4-Year Overall Survival (Hamlin, 2003)
0
low
74%
1
intermediate
49%
2 or 3
high
18%
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