Gallagher et al used the STOPP (Screening Tool of Older Person's Prescriptions) to help guide therapy in older adults. An important category are those used for patients with gastrointestinal or genitourinary disorders. The authors are from Cork University in Ireland.
Patient selection: age >= 65 years
Respiratory Drug |
Comorbid |
Other |
Adverse Effect |
theophylline monotherapy |
COPD |
|
safer alternative, narrow therapeutic index |
systemic corticosteroids, long-term maintenance |
moderate to severe COPD |
|
adverse side effects of corticosteroids |
nebulized ipatropium |
glaucoma |
|
glaucoma exacerbation |
Endocrine Drug |
Comorbid |
Other |
Adverse Effect |
glibenclamide or chlorpropamide |
type 2 diabetes |
|
hypoglycemia |
beta blockers |
diabetes mellitus with hypoglycemic episodes |
|
masking of hypoglycemic symptoms |
estrogens |
breast cancer |
|
risk of cancer recurrence |
estrogens |
venous thrombo-embolism |
|
risk of recurrent thrombosis |
estrogens without progresterone |
intact uterus |
|
endometrial hyperplasia and cancer |
Specialty: Pharmacology, clinical