The National Lipid Association (NLA) has listed criteria for when to suspect familial hypercholesterolemia (FH) in a patient.
Parameters
(1) serum LDL cholesterol
(2) serum non HDL-cholesterol
|
Age
|
LDL-Cholesterol
|
Non-HDL-Cholesterol
|
|
< 20 years
|
>= 160 mg/dL
|
>= 190 mg/dL
|
|
>= 20 years
|
>= 190 mg/dL
|
>= 220 mg/dL
|
In the general population the following serum LDL-Cholesterol concentrations are associated with an 80% probability of familial hypercholesterolemia.
|
Age
|
LDL-Cholesterol
|
|
< 20 years
|
>= 190 mg/dL
|
|
20 to 29 years
|
>=220 mg/dL
|
|
>= 30 years
|
>= 250 mg/dL
|
Additional information to collect:
(1) family history of high cholesterol
(2) premature coronary artery disease (< 55 years in males, < 65 years in females)
(3) tendon xanthomas
(4) arcus corneae at age < 45 years
(5) tuberous xanthomas or xanthelasma at age < 20 years
