Physiologic screening criteria - all of the following:
(1) heart rate < 140 beats per minute
(2) oxygen saturation > 92%
(3) FIO2 < 35%
(4) cough reflex intact
Exclusion of high-risk conditions:
(5) absence of unstable coronary artery disease
(6) absence of increased intracranial pressure
(7) absence of other unstable features (FIO2 > 50%, vasopressors required to maintain blood pressure, temperature > 39°C or < 36°C, heart rate > 150 beats per minute, respiratory rate > 35 or < 8)
Ventilator-associated factors:
(8) PEEP < 8 cm H2O
(9) pressure-support mode ventilation with pressure < 8 cm H2O
Since the paper demonstrated that adrenal insufficiency was associated with impaired weaning, an additional criteria can be added:
(10) adequate adrenal reserve or appropriate hydrocortisone supplementation
