Valcarcel et al developed a score for identifying a patient with acute myeloid leukemia (AML) who is at increased risk for death during induction therapy. The authors are from multiple universities in Spain.
Induction chemo therapy: anthracycline plus cytarabine
Parameters:
(1) age in years
(2) white blood cell count
(3) serum creatinine
Parameter
Finding
Points
age in years
< 50 years of age
0
>= 50 years of age
1
white blood cell count
<= 100,000 per µL
0
> 100,000 per µL
1
serum creatinine
<= 1.2 mg/dL
0
> 1.2 mg/dL
1
risk score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 3
• The higher the score the greater the risk for death during induction therapy.
Score
Hazard Ratio
Cumulative Mortality at 6 Weeks
0
1
6%
1
2.5
13-18%
2 or 3
5.4
26-30%
estimated from Figures 1 and 2
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