The score for death from osteosarcoma (SDOS) and the score for progression of osteosarcoma (SPOS) were developed by Taylor et al for evaluating risk in patients with osteosarcoma arising in bone. These are based on clinical findings in the patient and the pathologic features of the tumor.
|
Characteristic |
Weight for Death Score |
Weight for Progression Score |
|---|---|---|
|
juxtacortical |
|
-1.95 |
|
Paget's disease |
+3.85 |
+1.16 |
|
osteoblastic, chondroblastic, fibroblastic, or telangiectatic |
+1.15 |
|
|
site in humerus, clavicle, scapula or proximal femur |
+0.92 |
|
|
site is humerus, clavicle, scapula or proximal femur |
+0.63 |
|
|
regional spread of disease |
+0.84 |
+0.62 |
|
tumor grade 3 or 4 (high grade) |
+0.60 |
+1.34 |
|
tumor grade not given |
|
+0.95 |
|
size >= 20 cm |
+1.31 |
+0.86 |
|
duration of symptoms < 12 months |
+1.93 |
+0.90 |
|
weight loss >= 10 lbs (4.5 kgs) |
+0.72 |
+0.72 |
|
swelling noted at site |
+0.44 |
|
|
bone expansion reported |
|
-0.44 |
|
predominantly lytic in appearance |
+0.43 |
+0.40 |
other sites not listed above: jaw, distal to proximal femur, or distal to elbow
score for death from osteosarcoma (SDOS) =
= SUM(weights for death score present)
score for progression of osteosarcoma (SPOS) =
= SUM(weights for progression score present)
Interpretation
|
SDOS |
Risk Group |
2 year survival |
5 year survival |
|---|---|---|---|
|
< 3.00 |
low |
95% |
90% |
|
3.00 to 4.99 |
medium-low |
80% |
70% |
|
5.00 to 5.99 |
medium-high |
65% |
50% |
|
>= 6.00 |
high |
22% |
10% |
(survival estimated from Figure 3, page 28)
|
SPOS |
Risk Group |
2 year survival |
5 year survival |
|---|---|---|---|
|
< 1.50 |
low |
92% |
84% |
|
1.50 to 2.49 |
medium-low |
65% |
54% |
|
2.50 to 2.99 |
medium-high |
40% |
32% |
|
>= 3.00 |
high |
23% |
20% |
(survival estimated from Figure 5, page 28)
After 5 years the survival curves flatten out, extending onwards to 7 to 9 years.
Purpose: To predict the risk of death and tumor progression in a patient with osteosarcoma arising in bone using the scores of Taylor et al.
Specialty: Hematology Oncology, Surgery, general, Surgery, orthopedic
Objective: risk factors, criteria for diagnosis, severity, prognosis, stage, options
ICD-10: C40-C41,
