Nosocomial pneumonia is an important problem for patients in the intensive care unit (ICU). 7 parameters were identified by multivariate analysis as being associated with nosocomial pneumonia in ICU patients. These parameters can be used to generate 2 simple scores which can be used to stratify patients by risk shortly after admission, thereby allowing better management.
Patients studied:
(1) Patients were >= 18 years of age.
(2) Study performed at University of Freiburg, Germany from July, 1991 to July 1993.
Parameter Associated with Nosocomial Pneumonia |
Relative Risk |
95% Confidence Intervals |
---|---|---|
no infection on admission |
3.1 |
2.0 - 4.8 |
thorax drainage |
2.1 |
1.2 - 3.5 |
administration of antacids |
2.1 |
1.4 - 3.1 |
PaO2 > 110 mm Hg |
1.6 |
1.0 - 2.6 |
administration of coagulation factors |
1.8 |
1.0 - 3.2 |
male gender |
2.7 |
1.2 - 6.3 |
urgent surgery |
2.4 |
0.9 - 6.4 |
where:
• administration of coagulation factors indicates either use of fresh frozen plasma (FFP) or antithrombin III concentrates
Score for Predicting Pneumonia During Week 1
Parameter |
Finding |
Points |
---|---|---|
infection on admission |
present |
0 |
|
absent |
11 |
thorax drainage |
present |
7 |
|
absent |
0 |
antacids |
given |
7 |
|
not given |
0 |
PaO2 |
> 110 mm Hg |
5 |
|
<= 110 mm Hg |
0 |
administration of coagulation factors |
given |
6 |
|
not given |
6 |
score 1 =
= SUM(points for findings present)
Score for Predicting Pneumonia During Week 2
Parameter |
Finding |
Points |
---|---|---|
infection on admission |
present |
0 |
|
absent |
11 |
thorax drainage |
present |
7 |
|
absent |
0 |
antacids |
given |
7 |
|
not given |
0 |
PaO2 |
> 110 mm Hg |
5 |
|
<= 110 mm Hg |
0 |
gender |
male |
10 |
|
female |
0 |
type of surgery |
urgent |
9 |
|
elective |
0 |
neurological disease |
present |
14 |
|
absent |
0 |
score 2 =
= SUM(points for findings present)
Interpretation:
• minimum score 1 and score 2: 0
• maximum score 1: 36
• maximum score 2: 63
Score 1 |
Group |
Percent with Pneumonia for days 1-6 |
---|---|---|
0 - 10 |
I |
5.9% |
11 - 15 |
II |
9.3% |
16 - 21 |
III |
10.8% |
>= 22 |
IV |
26.5% |
Table 5, page 1159
Score 2 |
Group |
Percent with Pneumonia for days 7-14 |
---|---|---|
0 - 17 |
I |
6% |
18 - 24 |
II |
8.4% |
25 - 30 |
III |
26.1% |
>= 31 |
IV |
11.6% |
Table 5, page 1159
Cumulative Risk
Note: The paper is a little vague in how the data in Table 6 (page 1159) is calculated. I have elected to use the score of all parameters for this, but it may be that only Score 1 is used, since the breakpoints are the same. Alternatively it could be based on findings for no infections, thoracic drainage, use of antacids and PaO2.
Score |
Group |
Percent with Pneumonia by Day 14 |
---|---|---|
0 - 10 |
I |
11% |
11 - 15 |
II |
17.5% |
16 - 21 |
III |
18.4% |
>= 22 |
IV |
42.3% |
Purpose: To use 2 clinical scores to identify an ICU patient at risk for nosocomial pneumonia.
Specialty: Infectious Diseases, Pulmonology
Objective: risk factors, complications
ICD-10: J12, J13, J14, J15, J16, J17, J18,