Sun et al reported a score for predicting the risk of invasive fungal infection in a patient receiving an allogeneic hematopoietic stem cell transplant. The authors are from multiple institutions in China.
Patient selection: allogeneic hematopoietic stem cell transplant
Parameters:
(1) absolute neutrophil count per microliter
(2) corticosteroid therapy
(3) diabetes mellitus
(4) haploidentical donor
(5) unrelated donor
Parameter
Finding
Points
absolute neutrophil count
>= 500 per µL
0
< 500 per µL
3
corticosteroid therapy
no
0
yes
3
diabetes mellitus
no
0
yes
3
haploidentical donor
no
0
yes
2
unrelated donor
no
0
yes
3
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 14
• The higher the score the greater the risk.
• The risk can be significantly reduced by giving prophylaxis.
Total Score
Risk Group
0 to 4
low
5 to 8
intermediate
9 to 14
high
Risk
Without Prophylaxis
With Prophylaxis
low
3.8%
2.1%
intermediate
18.5%
8.5%
high
30.8%
19.4%
Performance:
• The area under the ROC curve was 0.73 for the derivation and 0.66 for the validation cohorts.
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