Rades et al developed a score for evaluating a patient with brain metastases who has been treated with whole brain radiotherapy. The authors are from University Hospital Schleswig-Holstein and the Mayo Clinic Scottsdale.
Patient selection: brain metastases (all tumor types) treated with whole brain radiotherapy (WBRT)
Parameters:
(1) age of the patient in years
(2) Karnofsky Performance Status (KPS)
(3) extracranial metastases present at the time of whole brain radiotherapy
(4) number of months between tumor diagnosis and whole brain radiotherapy
|
Parameter |
Finding |
Points |
|
age in years |
<= 60 years |
4 |
|
|
>= 61 years |
3 |
|
KPS |
>= 70 |
5 |
|
|
< 70 |
1 |
|
extracranial metastases |
no |
5 |
|
|
yes |
2 |
|
number of months |
<= 8 months |
3 |
|
|
> 8 months |
4 |
total score =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score: 9
• maximum score: 18
• The higher the score the better the long-term survival.
• A patient expected to have a better long-term survival may benefit from longer-course whole brain radiotherapy since it is associated with less neurocognitive toxicity.
|
Total Score |
Group |
6 Month Survival |
|
9 or 10 |
A |
6% |
|
11 to 13 |
B |
15% |
|
14 to 16 |
C |
43% |
|
17 or 18 |
D |
76% |
Specialty: Hematology Oncology, Surgery, general
ICD-10: ,
