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Score of Kilic et al for Predicting the Risk of Rejection After Orthotopic Heart Transplantation

Description

Kilic et al developed a simple score for evaluating the risk of rejection following orthotopic heart transplantation. This can help to identify a patient who may benefit from more aggressive management. The authors are from the Johns Hopkins University and Yale University.


 

Patient selection: heart transplant

 

Outcome: 1-year rejection

 

Parameters:

(1) age in years

(2) gender

(3) race (White, Black, Hispanic, Asian, other)

(4) HLA mismatch

 

Parameter

Finding

Points

age in years

< 40 years

4

 

40 to 49.9 years

3

 

50 to 59.9 years

2

 

>= 60 years

0

race

non-Asian

4

 

Asian

0

gender

Male

0

 

Female

3

HLA mismatch

4 to 6 (high degree)

2

 

less than 4

0

 

total score =

= SUM(points for all 4 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 13

• The higher the score the greater the risk of rejection.

 

Score

1 Year Rejection Raee

0 to 5

20%

6 to 9

33%

10 to 13

44%

 

Performance:

• The area under the ROC curve was 0.67.

 


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