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Score of Kessoku et al for Predicting Cirrhosis in Nonalcoholic Fatty Liver Disease (NAFLD, PLALA Score)

Description

Kessoku et al reported a score for predicting cirrhosis in a patient with nonalcoholic fatty liver disease (NAFLD). This is a simple score that can help to identify a patient who may need additional studies. The authors are from multiple institutions in Japan and members fo the Japan Study Grop of NAFLD.


PLALA is an acronym for platelet, albumin and AAR.

 

Patient selection: non-alcoholic fatty liver disease (NAFLD)

 

Parameters:

(1) platelet count per microliter

(2) serum albumin in g/dL

(3) AST to ALT ratio (AAR)

 

Parameter

Finding

Points

platelet count

>= 153,000 per µL

0

 

< 153,000 per µL

1

serum albumin

>= 4.0 g/dL

0

 

< 4.0 g/dL

1

AST to ALT ratio

<= 0.9

0

 

> 0.9

1

 

total score =

= SUM(points for all of the parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 3

• A score >= 2 is associated with stage 4 liver fibrosis (cirrhosis).

 

Performance:

• The sensitivity is 87% and specificity 91%.

• The negative predictive value is reported 99.5%

• The positive predictive value is 26%.

 


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