Jansen et al developed a score for predicting the 12-month mortality rate for a patient with a diffuse intrinsic pontine glioma (DIPG). The authors are from multiple hospitals in Europe.
Patient selection: child with DIPG
Outcome: 12 month mortality
Parameters:
(1) age of the patient in years
(2) symptom duration in months
(3) ring enhancement on T1-weighted MRI with contrast
(4) therapy
|
Parameter |
Finding |
Points |
|
age in yers |
< 3 years old |
0 |
|
|
>= 3 years old |
7 |
|
symptom duration in months |
|
(-1)*<months> |
|
ring enhancement |
absent |
0 |
|
|
present |
4 |
|
therapy |
radiation therapy only |
0 |
|
|
radiation plus oral or intensive chemotherapy |
-4 |
total score =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score: varies with symptom duration but could be less than 0
• maximum score 11
• The higher the score the worse the 12-month mortality.
• The median survival in the study population was 10 months.
|
Score |
Predicted Mortality |
Risk Group |
|
< 1 |
47% |
standard |
|
1 or 2 |
60% |
intermediate |
|
3 to 5 |
67% |
intermediate |
|
6 |
74% |
intermediate |
|
7 to 11 |
80% |
high |
Specialty: Hematology Oncology, Surgery, general, Neurology
