Heo et al reported a clinical score for distinguishing severe fever with thrombocytopenia from other endemic zoonoses in Korea. The authors are from multiple institutions in South Korea.
Patient selection: adult diagnosed with endemic zoonosis in South Korea
Parameters:
(1) neurological symptoms (GCS < 15, tremor, motor weakness, dysarthria)
(2) diarrhea
(3) leukopenia (WBC count < 4,000 per µL)
(4) serum CRP
Parameter
Finding
Points
neurological symptoms
no
0
yes
1
diarrhea
no
0
yes
1
leukopenia
no
0
yes
1
serum CRP
normal
1
elevated
0
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 4
• A score >= 2 has a sensitivity of 0.83 and specificity of 0.96 for severe fever with thrombocytopenia syndrome.
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