Goel et al developed a semiquantitative score for evaluating a patient for the familial antiphospholipid antibody syndrome. The sum of the 3 subscores is used to evaluate the proband and family members with evidence of antiphospholipid antibody syndrome. The authors are from multiple universities and hospitals in the United States and Canada.


Inheritance in familial antiphospholipid antibody syndrome: autosomal dominant


cumulative score =

= (points for clinical subscore) + (points for coagulation testing subscore) + (points for serologic testing subscore)



• minimum cumulative score: 0

• maximum cumulative score: 9


Diagnostic criteria for proband - one or more of the following:

(1) cumulative score >= 5 AND clinical subscore =3 AND serologic subscore >= 2 AND no exclusionary features

(2) cumulative score >= 5 AND clinical subscore =3 AND coagulation subscore =3 AND no exclusionary features


Exclusionary features for proband:

(1) SLE

(2) other hypercoagulable state (protein C deficiency, etc)

(3) therapy with a drug known to trigger antiphospholipid antibodies


Diagnostic criteria for an affected family members - one or more of the following:

(1) cumulative score >= 4 AND serologic subscore >= 1

(2) serologic subscore >= 2

(3) coagulation subscore = 3


To read more or access our algorithms and calculators, please log in or register.