Major clinical manifestations:
(1) acute myocardial infarction < 45 years of age
(2) stroke at age < 60 years
(3) other arterial thromboembolic event
(4) venous thromboembolic event (deep venous thrombosis and/or pulmonary embolism)
(5) recurrent fetal loss during second and/or third trimester (in females)
Minor clinical manifestations:
(1) superficial thrombophlebitis
(2) recurrent first trimester miscarriages
(3) livido reticularis
(4) valvular heart disease
(5) leg ulcerations
(6) migraine and/or migranous phenomenon
(7) mucosal ulcerations
(8) seizures
(9) myelopathy
(10) neuropsychiatric manifestations
(11) Sjogren’s syndrome or other associated rheumatologic conditions (family members only)
|
Major
|
Minor
|
Other
|
Points
|
|
1 or more
|
NA
|
NA
|
3
|
|
none
|
1 or more
|
thrombocytopenia not due to other cause
|
2
|
|
none
|
1 or more
|
thrombocytopenia due to another cause or normal platelet count
|
1
|
|
uncertain
|
NA
|
NA
|
1
|
|
none
|
none
|
none
|
0
|
where:
• A major clinical manifestations that is considered uncertain: AMI at age > 45 years, stroke at age > 60 years.
