Fernandez-Banares et al reported a score for the diagnosis of low-grade celiac enteropathy in a patient with lymphocytic enteritis. The authors are from Hospital Universitari Mutua Terrassa in Barcelona and CIBERehd in Madrid.
Parameters:
(1) serum anti-transglutaminase antibodies
(2) serum anti-endomysium antibodies
(3) intraepithelial lymphocyte pattern (CD3+ T-cell gamma delta+)
(4) intraepithelial lymphocyte count per 100 epithelial cells, in percent
(5) celiac genetics
Anti-Transglutaminase Abs
Anti-Endomysium Abs
Points
> 20 U/mL
NA
10
8.01 to 20 U/mL
6
2.01 to 8.0 U/mL
positive
negative
2
<= 2 U/mL
0
Parameter
Finding
CD3+ T-cell gamma delta+intraepithelial lymphocytes
increased +
7
not increased
intraepithelial lymphocyte count
> 25%
5
19 to 25%
< 19%
-1
celiac genetics
DQ2.5 positive
3
DQ8 and DQ2.2 positive
allele DQB1 of haplotype DQ2.5 positive
2 alleles DQ2.5- and DQ8-
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: -2
• maximum score: 25
• A score > 10 is associated with celiac enteropathy (sensitivity 0.86, specificity 0.85).
Performance:
• The area under the ROC curve is 0.91.
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Specialty: Gastroenterology
