Score of Dutto et al for Insignificant Prostate Cancer

Description

Dutto et al developed a risk score for identifying a patient with insignificant prostate cancer. The authors are from St Antonius Hospital in Gronau, Queen Elizabeth University Hospital, Queen Mary University of London and University College London.

Patient selection: Gleason score 3+3 or less

Parameters:

(1) serum PSA in ng/mL

(2) prostate volume in mL by transrectal ultrasonography (TRUS)

(3) age in years

(4) clinical stage

(5) percentage of positive cores

(6) number of positive cores

percentage of positive cores =

= (number of positive cores) / (total number of cores) * 100%

Parameters	Finding	Points
serum PSA		-1.227 * LOG10(1 + (PSA))
prostate volume		0.022 * (volume)
age in years		-0.050 * (age)
clinical stage	cT1a	-4*0.301
	cT1b	-5*0.301
	cT1c	-6*0.301
	cT2a	-7*0.301
	cT2b	-8*0.301
	cT2c	-9*0.301
percent cores positive		-0.016 * (percent)
number of positive cores		-0.08 * (number)

novel risk score = NRS =

= SUM(points for all of the parameters)

equation =

= EXP((NRS)+7.504432)

Interpretation:

• The cutoff for high sensitivity was -8.013.

• The cutoff for high specificity is -6.600

An online version is at www.evidencio.com/models/show/1391.

Performance:

• The area under the ROC curve is 0.76.

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Score of Dutto et al for Insignificant Prostate Cancer

Description

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