Corso et al reported a scoring system for collection of stem cells from peripheral blood in patients with multiple myeloma. This can help to predict the yield of the mobilizing procedure. The authors are from the University of Pavia and IRCCS Policlinico San Matteo in Italy.
Procedure: stem cell collection from peripheral blood
Patient selection: multiple myeloma
Stem cell mobilization protocol: high-dose cyclophosphamide followed by G-CSF 48 hours after chemotherapy
Cut-off for CD34+ cells: 2 * 10^6 per kg body weight
Parameters:
(1) WBC count
(2) platelet count
(3) prior exposure to melphalan (alkylating agents)
(4) interval in months since the start of treatment
Parameter
Finding
Points
WBC count
normal or high
0
low
1
platelet count
normal or high
0
low
1
prior melphalan
no
0
yes
1
interval in months
<= 6 months
0
> 6 months
1
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 4
Score
Probability of Collecting LT 4 * 10^6 CD34+/kg
0
3%
1
11%
2
32%
3
57%
4
85%
Additional factors (mentioned but not included in score):
(1) prior exposure to radiotherapy
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