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Score of Biewenga et al for Survival in a Patient with Cervical Cancer

Purpose: To predict the prognosis for a woman with an early stage cervical cancer using the score of Biewenga et al.

Description

Biewanga et al developed a score for predicting disease-specific survival for a patient with early stage cervical cancer. This can help to identify a patient who may benefit from more aggressive management. The authors are from the Academic Medical Center in Amsterdam.


Patient selection: FIGO Stage IA2 to IIA.

 

Parameter:

(1) histologic features

(2) tumor diameter in mm

(3) depth of stromal invasion in percent

(4) lymph node metastases

(5) parametrial extension

(6) lymphovascular space invasion

 

Parameter

Finding

Points

histology

squamous

0

 

adenosquamous

1

 

adenocarcinoma

4

tumor diameter

< 20 mm

0

 

20 to 60 mm

1

 

> 60 mm

4

depth of stromal invasion

< 33%

0

 

33 to 67%

1

 

> 67%

3

lymph node metastases

no

0

 

yes

3

parametrial nvasion

no

0

 

yes

3

lymphovascular space invasion

no

0

 

yes

2

 

total score =

= SUM(points for all 6 parameters)

 

Interpretation:

• minimum score: 0

• maxium score: 19

• The higher the score the worse the prognosis.

 

Score

Estimated  5-Year Disease-Specific Survival

0 or 1

> 99%

2 to 8

(-0.1429 * ((score)^2)) + (0.4929 * (score)) + 98.48

9 to 16

(-0.8650 * ((score)^2)) + (12.81 * (score)) + 45.38

17 to 19

< 25%

 


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Specialty

Objective

ICD-10