Systemic sclerosis may affect internal organs in addition to the skin. Medsger et al developed severity scales to grade severity of end-organ damage in affected organs. The authors are from multiple universities in North America and Europe.
Parameters:
(1) weight loss
(2) hematocrit (packed cell volume, PCV)
(3) total skin thickness score (TSS)
General Severity Scale (GSS)
Weight Loss
Hematocrit
GSS Grade
< 5 kg
>= 37%
0 (normal)
5 to 9.9 kg
33 to 36.9%
1 (mild)
10 to 14.9 kg
29 to 32.9%
2 (moderate)
15 to 19.9 kg
25 to 28.9%
3 (severe
>= 20 kg
< 25%
4 (endstage)
Skin Severity Scale (SSS)
Total Skin Thickness Score
SSS Grade
0
0 (normal)
1 to 14
1 (mild)
15 to 29
2 (moderate)
30 to 39
3 (severe
>= 40
4 (endstage)
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