Scleredema adultorum was described by Buschke and is classified as a type of mucinosis.



(1) diffuse swelling, hardening and/or induration of the skin

(2) marked thickening of the dermis with mucin between swollen collagen bands

(3) involvement of face and trunk with relative sparing of the extremities

(4) absence of Raynaud's phenomenon

(5) exclusion of other infiltrative or fibrosing disorders (especially for patients with diabetes or paraproteinemia. POEMS syndrome)


Conditions associated with scleredema adultorum:

(1) diabetes mellitus

(2) monoclonal gammopathy or multiple myeloma

(3) infection

(4) hyperparathyroidism


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