Injection into the buttocks of an infant or child can result in damage to the sciatic nerve.

Preferred site for vaccine injection: deltoid muscle or anterolateral thigh


Risk factors for nerve injury:

(1) large volume injected

(2) highly irritant solution

(3) deep injection near the course of the sciatic nerve


A subcutaneous injection of a small volume of vaccine may be feasible but other sites are preferrable.


If a large volume of vaccine or antiserum must be given, then administration at multiple sites is to be preferred over the buttocks.

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