The SAFEHEART score predict the risk of cardiovascular events in a patient with familial hypercholesterolemia. The authors are from multiple institutions in Spain participating in the Spanish Familial Hypercholesterolemia Cohort Study.
Patient selection: familial hypercholesterolemia
Parameters:
(1) age in years
(2) sex
(3) history of arteriosclerotic cardiovascular disease (ASCVD)
(4) hypertension
(5) body mass index (BMI)
(6) smoking
(7) serum LDL cholesterol in mg/dL
(8) serum lipoprotein A in mg/dL
Parameter
Finding
Odds Ratio
LN (OR) = beta-ceofficients
age in years
< 30
1
0
30 to 59
2.92
1.07
>= 60
4.27
1.45
sex
male
2.01
0.7
female
1
0
ASCVD
no
1
0
yes
4.15
1.42
hypertension
no
1
0
yes
1.99
0.69
BMI
normal
1
0
overweight
2.4
0.88
obese (> 30)
2.67
0.98
smoking
no
1
0
yes
1.62
0.48
LDL cholesterol
< 100
1
0
100 to 159
2.5
0.92
>= 160
4.8
1.57
lipoprotein A
<= 50
1
0
> 50
1.52
0.42
value of X =
= SUM(points for beta coefficients) - 5.4078
5-year risk of ASCVD =
= 1 - (0.9532 ^(EXP(X)))
10-year risk of ASCVD=
= 1 - (0.9025 ^(EXP(X)))
Performance:
• The area under the ROC curve is 0.85.
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