The SAFEHEART score predict the risk of cardiovascular events in a patient with familial hypercholesterolemia. The authors are from multiple institutions in Spain participating in the Spanish Familial Hypercholesterolemia Cohort Study.
Patient selection: familial hypercholesterolemia
Parameters:
(1) age in years
(2) sex
(3) history of arteriosclerotic cardiovascular disease (ASCVD)
(4) hypertension
(5) body mass index (BMI)
(6) smoking
(7) serum LDL cholesterol in mg/dL
(8) serum lipoprotein A in mg/dL
Parameter |
Finding |
Odds Ratio |
LN (OR) = beta-ceofficients |
age in years |
< 30 |
1 |
0 |
|
30 to 59 |
2.92 |
1.07 |
|
>= 60 |
4.27 |
1.45 |
sex |
male |
2.01 |
0.7 |
|
female |
1 |
0 |
ASCVD |
no |
1 |
0 |
|
yes |
4.15 |
1.42 |
hypertension |
no |
1 |
0 |
|
yes |
1.99 |
0.69 |
BMI |
normal |
1 |
0 |
|
overweight |
2.4 |
0.88 |
|
obese (> 30) |
2.67 |
0.98 |
smoking |
no |
1 |
0 |
|
yes |
1.62 |
0.48 |
LDL cholesterol |
< 100 |
1 |
0 |
|
100 to 159 |
2.5 |
0.92 |
|
>= 160 |
4.8 |
1.57 |
lipoprotein A |
<= 50 |
1 |
0 |
|
> 50 |
1.52 |
0.42 |
value of X =
= SUM(points for beta coefficients) - 5.4078
5-year risk of ASCVD =
= 1 - (0.9532 ^(EXP(X)))
10-year risk of ASCVD=
= 1 - (0.9025 ^(EXP(X)))
Performance:
• The area under the ROC curve is 0.85.
Specialty: Cardiology