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Ruxolitinib Withdrawal Syndrome (Ruxolitinib Discontinuation Syndrome)

Specialty:

Clinical Pharmacology & Toxicology
Emergency Medicine & Critical Care
Emergency Medicine & Critical Care

Objective:

ICD-10:

Description:

Ruxolitinib (INCB018424) is an inhibitor of JAK1 and JAK2 used in the treatment of myelofibrosis. Discontinuation of therapy may be followed by a withdrawal reaction that can be severe. This syndrome may be mediated by rapid changes in cytokine activity.

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