ROHHAD and ROHHADNET are acronyms for rare pediatric disorders.


(1) rapid-onset obesity (RO) secondary to hyperphagia

(2) hypothalamic dysfunction (H)

(3) hypoventilation (H)

(4) autonomic dysfunction (AD; dysautonomia)


ROHHADNET is ROHHAD plus a neuroendocrine tumor (NET).


Additional clinical features may include:

(1) growth failure (pituitary)

(2) glucocorticoid insufficiency (pituitary)

(3) congenital hypopituitarism (hypothalamic)

(4) hyperprolactinemia

(5) behavioral disorders (depression, psychosis, obsessive-compulsive disorder, Tourette's)

(6) cardiopulmonary arrest

(7) fixed pupils and/or anisocoria

(8) temperature dysregulation with fever (hypothalamic)

(9) electrolyte abnormalities

(10) gastrointestinal dysmotility


In the patient described by Sethi et al the patient had a hypothalamic encephalitis.


Neuroendocrine tumors may show neurological paraneoplastic syndromes.

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