Patient selection: hepatoblastoma
Parameters:
(1) PRETEXT group (I, II, III, IV)
(2) age in years
(3) VPEFR status at diagnosis (vena cava, portal vein, extrahepatic, multifocal, rupture)
(4) serum AFP in ng/mL
(5) resectability
(6) distant metastases
Very low risk:
(1A) PRETEXT I, nonmetastatic, VPEFR negative, resectable at diagnosis
(1B) PRETEXT II, nonmetastatic, < 8 years old, AFP > 100 ng/mL, VPEFR negative, resectable at diagnosis
Low risk:
(2A) PRETEXT 1, nonmetastatic, VPEFR negative, not resectable at diagnosis
(2B) PRETEXT II, nonmetastatic, < 8 years old, AFP > 100 ng/mL, VPEFR negative, not resectable at diagnosis
(2C) PRETEXT III, nonmetastatic, < 8 years old, AFP > 1000 ng/mL, VPEFR negative
Intermediate risk:
(3A) PRETEXT I, nonmetastatic, VPEFR positive, < 8 years of age
(3B) PRETEXT II, nonmetastatic, < 8 years old, AFP > 100 ng/mL, VPEFR positive
(3C) PRETEXT III, nonmetastatic, < 8 years old, AFP > 1000 ng/mL, VPEFR positive
(3D) PRETEXT III, nonmetastatic, < 8 years old, AFP 101- 1000 ng/mL
(3E) PRETEXT IV, nonmetastatic, < 3 years old, AFP >100 ng/mL
High risk:
(4A) metastatic disease
(4B) PRETEXT I, nonmetastatic, VPEFR positive, >= 8 years of age
(4C) PRETEXT II, nonmetastatic, < 8 years old, AFP <= 100 ng/mL
(4D) PRETEXT II, nonmetastatic, >= 8 years old
(4E) PRETEXT III, nonmetastatic, < 8 years old, AFP <= 100 ng/mL
(4F) PRETEXT III, nonmetastatic, >=8 years old
(4G) PRETEXT IV, nonmetastatic, < 3 years old, AFP <=100 ng/mL
(4H) PRETEXT IV, nonmetastatic, >= 3 years old
