Suh et al reported 2 risk scores for a patient with papillary thyroid carcinoma. This can help to identify a patient who may benefit from more aggressive management. The authors are from Dong-A University, Pusan National University and Chung-Ang University in South Korea.
Patient selection: papillary thyroid carcinoma
Parameters:
(1) sex
(2) tumor size in cm
(3) microscopic extrathyroidal extension
(4) BRAF mutation
(5) TERT mutation
(6) histologic type
(7) lymph node metastases
(8) distant metastases
In this score the points assigned is the LN of the value given in the RSS1 score.
Parameter
Finding
Points
sex
female
ln(1) = 0
male
ln(1.53) = 0.43
tumor size
<= 2 cm
ln(1) = 0
> 2 cm
ln(2.69) = 0.99
extrathyroidal extension
no
ln(1) = 0
yes
ln(2.83) = 1.04
BRAF mutation
no
ln(1) = 0
yes
ln(3.34) = 1.21
TERT mutation
no
ln(1) = 0
yes
ln(5.73) = 1.75
histologic type
follicular
ln(0.52) = -0.65
diffuse sclerosing
ln(3.19) = 1.16
classic
ln(1) = 0
other
ln(1) = 0
lymph node metastasis
no
ln(1) = 0
yes
ln(3.24) = 1.18
distant metastases
no
ln(1) = 0
yes
ln(11.96) = 2.48
total score =
= SUM(points for all 8 parameters)
Interpretation:
• minimum score: -0.65
• maximum score: 10.24
• A score < 2.03 is designated low risk.
• A score >= 2.03 is designated high risk.
Performance:
• The area under the ROC curve is 0.56, which is less than the area for RSS1.
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