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Risk Scores of Mocroft at al for Chronic Kidney Disease (CKD) in a Patient with HIV in the D:A:D Study: Full Model with Cardiovascular Risk Factors

Description

Mocroft et al developed risk scores for predicting chronic kidney disease in HIV patients enrolled in the D:A:D Study. The complete model can be used when cardiovascular risk factors are known. The authors are from multiple institutions in Europe, the United States and Australia.


 

Patient selection: HIV positie, estimated GFR > 60 mL per min per 1.73 square meters

 

Parameters:

(1) age in years

(2) gender

(3) intravenous drug user (and HIV exposure)

(4) hepatitis C coinfection

(5) baseline estimated GFR in mL per min per 1.73 square meter

(6) nadir absolute CD4 count per µL

(7) hypertension

(8) history of cardiovascular disease

(9) diabetes mellitus

 

Parameter

Finding

Points

age in years

<= 35 years

0

 

36 to 50 years

1.0813

 

51 to 60 years

2.0276

 

> 60 years

2.7841

gender

male

0

 

female

0.3982

intravenous drug user

no

0

 

yes

0.6556

hepatitis C coinfection

no

0

 

yes

0.3395

baseline eGFR

> 90

-1.6365

 

71 to 90

0

 

61 to 70

1.6475

nadir absolute CD4 count

<= 200 per microliter

0

 

> 200 per µL

-0.2848

hypertension

no

0

 

yes

0.2386

history of cardiovascular disease

no

0

 

yes

0.4097

diabetes mellitus

no

0

 

yes

0.5764

 

where:

• There is an alternative score using summation of assigned points.

 

X =

= SUM(points for all 9 parameters) – 6.2406

 

probability of CKD =

= 1 / (1 + EXP((-1) * X))

 


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