Risk Scores of Mocroft at al for Chronic Kidney Disease (CKD) in a Patient with HIV in the D:A:D Study: Full Model with Cardiovascular Risk Factors

Description

Mocroft et al developed risk scores for predicting chronic kidney disease in HIV patients enrolled in the D:A:D Study. The complete model can be used when cardiovascular risk factors are known. The authors are from multiple institutions in Europe, the United States and Australia.

Patient selection: HIV positie, estimated GFR > 60 mL per min per 1.73 square meters

Parameters:

(1) age in years

(2) gender

(3) intravenous drug user (and HIV exposure)

(4) hepatitis C coinfection

(5) baseline estimated GFR in mL per min per 1.73 square meter

(6) nadir absolute CD4 count per µL

(7) hypertension

(8) history of cardiovascular disease

(9) diabetes mellitus

Parameter	Finding	Points
age in years	<= 35 years	0
	36 to 50 years	1.0813
	51 to 60 years	2.0276
	> 60 years	2.7841
gender	male	0
	female	0.3982
intravenous drug user	no	0
	yes	0.6556
hepatitis C coinfection	no	0
	yes	0.3395
baseline eGFR	> 90	-1.6365
	71 to 90	0
	61 to 70	1.6475
nadir absolute CD4 count	<= 200 per microliter	0
	> 200 per µL	-0.2848
hypertension	no	0
	yes	0.2386
history of cardiovascular disease	no	0
	yes	0.4097
diabetes mellitus	no	0
	yes	0.5764

where:

• There is an alternative score using summation of assigned points.

X =

= SUM(points for all 9 parameters) – 6.2406

probability of CKD =

= 1 / (1 + EXP((-1) * X))

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Risk Scores of Mocroft at al for Chronic Kidney Disease (CKD) in a Patient with HIV in the D:A:D Study: Full Model with Cardiovascular Risk Factors

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