Juge et al reported scores for evaluating a patient with rheumatoid arthritis for the risk of subclinical interstitial lung disease (ILD). One score includes evaluation of MUC5B. The authors are from multiple institutions in France and Brigham and Women's Hospital.
Patient selection: rheumatoid arthritis
Parameters:
(1) MUC5B rs35705950 genotyping
(2) sex
(3) age at RA onset
(4) mean DAS28-ESR (based on the last 4 values)
Parameter
Finding
Points
rs35705950 MUC5B
GG
0
GT or TT
27
sex
female
0
male
28
age at RA onset
<= 49 years
0
50 to 58 years
25
> 58 years
50
mean DA28-ESR
< 2.9
0
2.9 to 4.3
23
> 4.3
39
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 144
• A total score > 51 indicates a patient at risk for subclinical interstitial lung disease.
Performance:
• The area under the ROC curve for the derivation cohort was 0.82 and 0.78 for the validation one.
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