Risk Score of Shi et al for a Patient with Myelodysplasia

Description

Shi et al reported a linear risk score for a patient with myelodysplasia. This includes genetic information and the red cell distribution width (RDW). The authors are from Chinese Academy of Medical Sciences & Peking Union Medical College, Cincinnati Children's Hospital and Imperial College London.

Patient selection: myelodysplasia

Parameters:

(1) age in years

(2) RDW in percent

(3) ASXL1 mutations

(4) PTPN11 mutations

(5) IPSS-revised karyotype, cytogenetic risk (very good, good, poor, very poot)

Parameter	Finding	Points
age in years	< 60 years	0
	>= 60 years	1
IPSS-R cytogenetic risk	very good or good	0
	poor	2
	very poor	2.5
RDW	low (<14.5%)	0
	high (>=14.5%)	2.5
ASXL1 mutation	no	0
	yes	1.5
PTPN11 mutation	no	0
	yes	3

score =

= SUM(points for all 5 parameters)

Interpretation:

• minimum score: 0

• maximum score: 10.5

Score	Risk	3-Year Survival
< 1.5 (0 or 1)	low	95%
1.5 to 3.0	intermediate	76%
>= 3.5	high	34% (median 24 months)

To read more or access our algorithms and calculators, please log in or register.

Risk Score of Shi et al for a Patient with Myelodysplasia

Description

Specialty