Risk Score of Minkowitz et al for Opioid-Related Adverse Drug Events (ORADE) in a Surgical Patient: Model for a Female Patient

Description

Minkowitz et al reported models for opioid-related adverse drug events (ORADE) in surgical patients. These can help to identify a female patient at high risk for adverse events who may benefit from alternative analgesia. The authors are from Memorial Herman City Medical Center (Houston), Pacira Pharmaceuticals, and Xcenda (Palm Harbor).

Patient selection: female surgical patient

Parameters:

(1) age in years (age constraints not mentioned)

(2) obesity (ICD-9 278)

(3) degenerative joint disease

(4) COPD

(5) asthma

(6) CHF

(7) cardiac dysrhythmia

(8) diabetes

(9) regional enteritis

(10) diverticulitis

(11) obstructive sleep apnea

Parameter	Finding	Points
age in years		0.0253 * (years)
obesity	no	0
	yes	0.1422
degenerative joint disease	no	0
	yes	0.4957
COPD	no	0
	yes	1.1957
asthma	no	0
	yes	0.411
CHF	no	0
	yes	0.3605
cardiac dysrhythmia	no	0
	yes	1.1335
diabetes	no	0
	yes	0.1303
regional enteritis	no	0
	yes	2.1388
diverticulitis	no	0
	yes	0.6724
obstructive sleep apnea	no	0
	yes	0.2276

total score =

= SUM(points for all of the parameters)

Interpretation:

• minimum score: 0.4399

• maximum score: determined by age, around 9.44

• A score >= 1.7204 indicates a high risk for an opioid-related adverse drug event.

Performance:

• The area under the ROC curve is 0.734.

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Risk Score of Minkowitz et al for Opioid-Related Adverse Drug Events (ORADE) in a Surgical Patient: Model for a Female Patient

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