Li et al reported scores for predicting the risk of venous thromboembolism (VTE) in a patient with lung cancer. The authors are from the First Affiliated Hospital of Sun Yat-sen University and the First Affiliated Hospital of Guangzhou Medical University in China.
Patient selection: lung cancer
Parameters:
(1) sex
(2) age in years
(3) clinical stage
(4) histology
(5) history of chemotherapy
(6) history of surgery (presumed lung tumor related)
(7) D-dimer in mg/L FEU
(8) history of central venous catheter (presumed recent)
Parameter
Finding
Points
Beta-Coefficient
sex
female
0
0
male
1
0.927
age in years
< 65 years
0
0
>= 65 years
1
0.818
clinical stage
I or II
0
0
III or IV
1
0.675
histology
adenocarcinoma
1
0.837
other
0
0
chemotherapy
no
0
0
yes
1
0.945
surgery
no
0
0
yes
1
0.740
D-dimer
<= 0.55 mg/L
0
0
> 0.55 mg/L
1
0.679
CVC
no
0
0
yes
2
1.519
total score using points =
= SUM(points for all 8 parameters)
X score =
= SUM(beta-coefficients for all 8 parameters) - 5.879
probability of VTE =
= 1 / (1 + EXP((-1) * X))
Interpretation:
• minimum total score: 0
• maximum total score: 9
Total Score
Risk
0 to 3
low
4 or 5
moderate
6 to 9
high
Performance:
• The area under the ROC curve was 0.82 for the development and 0.83 for the validation cohorts.
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