Risk Score of Dranitsaris et al for Predicting Chemotherapy-Induced Anemia in a Woman with for Breast Cancer

Parameters:

(1) hemoglobin before chemotherapy in g/L

(2) number of chemotherapy cycles received

(3) age in years

(4) platelet count

(5) prophylactic antibiotics

(6) adjuvant chemotherapy

where (see second column, page 857):

• CEF = cyclophosphamide, epirubicin, fluorouracil

• CAF = cyclophosphamide, doxorubicin, fluorouracil

• CMF = cyclophosphamide, methotrexate, fluorouracil

• FEC = fluorouracil, epirubicin, cyclophosphamide

• FAC = fluorouracil, doxorubicin, cyclophosphamide

• FEC100 = fluorouracil, epirubicin (at 100 mg per sq m), cyclophosphamide

• AC-T = doxorubicin, cyclophosphamide, paclitaxel

• AC = doxorubicin, cyclophosphamide

• MF = methotrexate, fluorouracil

risk score =

= (points for chemotherapy) + (points for age) + (points for platelet count) + (points for prophylactic antibiotics) + (points for adjuvant chemotherapy) - (0.25 * (hemoglobin before chemotherapy)) + 50

Interpretation:

• The higher the score the greater the risk of anemia.

• The logistic regression curve in Figure page 861 indicates a probability of 50% with a score of 25.1.