Brazauskas et report a score for predicting event-free survival for a patient with sickle cell disease who has had a hematopoietic stem cell transplant. The authors are from multiple institutions in the United States and Europe.
Patient selection: HSCT for sickle cell disease
Outcome: event-free survival
Parameters:
(1) age of the donor
(2) type of donor
Parameter
Finding
Points
age of the donor
<= 12 years
0
>= 13 years
1
type of donor
HLA matched sibling
0
HLA mismatched relative
2
matched unrelated donor
1
mismatched unrelated donor
2
total score =
= SUM(points for the 2 parameters)
Interpretation:
• minimum score: 0
• maximum score: 3
• The higher the score the worse the survival.
Score
Risk Group
3-Year EFS (Training)
0
good
92%
1
intermediate
87%
2 or 3
high
57%
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