The prognosis of a patient with an osteosarcoma is often determined by the presence of metastases. Dong et al reported a score for predicting metastatic potential based on expression in specific genes. The authors are from First Hospital of Qin Huangdao and Baotou Medical College in China.
Patient selection: osteosarcoma
Genes:
(1) RAB1
(2) CLEC3B
(3) FCGBP
(4) RNASE3
(5) MDL1
(6) ALOX5AP
(7) VMO1
(8) ALPK3 (higher expression in patients with metastatic osteosarcoma)
Gene
Expression
Points
RAB1
no
0
yes
-0.286
CLEC3B
no
0
yes
-0.073
FCGBP
no
0
yes
-0.061
RNASE3
no
0
yes
-0.548
MDL1
no
0
yes
-0.139
ALOX5AP
no
0
yes
-0.017
VMO1
no
0
yes
-0.002
ALPK3
no
0
yes
0.092
total score =
= SUM(points for all of the findings)
Interpretation:
• minimum score: -1.126
• maximum score: 0.092
• The higher the score the greater the risk of metastatic disease.
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