A patient with the nephrotic syndrome is at risk for hypercoagulability.
Pathogenesis: urinary excretion of physiologic anticoagulants (antithrombin III, protein S, protein C)
Types of thrombosis may include:
(1) deep vein with pulmonary embolism
(2) renal vein
(3) portal vein
(4) cerebral venous sinus
(5) coronary artery
(6) carotid artery
(7) femoral artery
Risk factors for thrombosis:
(1) type of glomerulopathy (membranous nephropathy, lupus nephritis, other)
(2) obesity (BMI >= 30 kg per square meter)
(3) sepsis
(4) intravenous corticosteroids
(5) hemoconcentration
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Specialty: Hematology Oncology
