Patient selection: pediatric patient on continuous renal replacement therapy (CRRT) with age range 0 to 20 (median 5 years)
Parameters:
(1) percentage fluid overload (according to the equation of Goldstein et al)
(2) gender
(3) age
(4) body weight
The most important risk factor was the percentage of fluid overload. The mortality risk was low if the fluid overload was low (< 10%) with a hazard ratio of 3 (Table 2). Avoiding fluid overload by early initiation of CRRT was recommended.
For patients with high fluid overload (>= 10%) the following hazard ratios (HRs) were reported in Table 3.
|
Parameter
|
Finding
|
HR
|
|
body weight
|
< 10 kg
|
1
|
|
|
>= 10 kg
|
3.7
|
|
age
|
< 12 years
|
3.1
|
|
|
>= 12 years
|
1
|
|
gender
|
male
|
2.8
|
|
|
female
|
6.9
|
where:
• Hazard ratios were gievne for age < 5 years and age < 12 years. The first had a hazard ratio of 2.9, which is close to that of the < 12 years.
cumulative hazard ratio =
= PRODUCT(hazard ratios for the 3 parameters)
Additional risk factors for mortality (from Table 2):
(1) use of pressors (HR 2)
(2) PRISM-2 score >= 11 (HR 1.7)
