Tsai et al identified risk factors associated with gallstones in men undergoing cycles of weight loss and weight regain. These can help identify a man who is at risk of cholelithiasis. The authors are from the University of Kentucky, Brigham and Women's Hospital, Harvard University and the National Cancer Institute.


Risk factors for gallstones associated with weight cycling:

(1) multiple cycles of weight loss and regain

(2) number of cycles involving moderate and severe cycles

(3) rapid weight loss

(4) high starting body mass index (or weight above ideal body weight in adipose tissue)

Weight Loss (Intentional)

Cycling Level


NA (weight maintainer)

5 to 9 pounds


10 to 19 pounds


>= 20 pounds



To read more or access our algorithms and calculators, please log in or register.