For a person who is at risk for an autosomal dominant disease and who has reached a certain age unaffected, the probability that the person will develop the disease by a certain future age can be predicted if the cumulative probabilities are known.
risk of developing the disease by the future age =
= ((cumulative risk for developing disease by future age) – (cumulative risk for developing disease by current age)) / (1 - (cumulative risk for developing disease by current age))
An example of this calculation is shown in the Claus model for breast carcinoma risk in the oncology chapter.
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