Patient selection: Chinese adult with Sjogren’s Syndrome
Risk factors for DVT and/or PE (comorbidities):
(1) atrial fibrillation
(2) diabetes mellitus
(3) history of cerebrovascular accident
(4) heart failure
(5) lower leg fracture or surgery
(6) cancer
(7) pregnancy
|
Sjogren’s
|
Comorbidity
|
HR DVT
|
HR PE
|
|
No
|
0
|
1
|
1
|
|
Yes
|
0
|
1.5
|
4.1
|
|
No
|
>= 1
|
1.7
|
3.6
|
|
Yes
|
>= 1
|
3.7
|
11.4
|
where:
• A patient with atrial fibrillation or lower leg surgery may be receiving anticoagulation therapy, which would lower the risk for DVT or PE.
• While some comorbid conditions would be lifelong, pregnancy and lower leg trauma would be transient risk factors.
A person with secondary Sjogren’s syndrome (associated with RA, SLE, PBC, or scleroderma) has a greater risk than a patient with primary Sjogren’s syndrome.
|
Sjogren Status
|
HR DVT
|
HR PE
|
|
none
|
1
|
1
|
|
primary
|
1.8
|
3.2
|
|
secondary
|
3.3
|
5.1
|
While the hazard ratios look significant, the cumulative incidence of DVT or PE in a patient with Sjogren’s syndrome over 10 years is 0.7% (Figure 1).
