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Risk of AIDS-Related Malignant Lymphoma in a Patient Based on Serum Free Light Chain Concentrations

Description

Landgren et al correlated serum free light chain concentrations in AIDS patients with the risk of developing a malignant lymphoma. Monitoring serum free light chains can help to identify AIDS patients with polyclonal B-cell activation and dysfunction who are at increased risk for developing malignant lymphoma. The authors are from the National Cancer Institute and Mayo Clinic.


 

Patient selection: AIDS patient

 

Parameters:

(1) serum free kappa light chain concentration in mg/dL

(2) upper limit of the normal (ULN) reference range for free kappa light chains

(3) serum free lamda light chain concentration in mg/dL

(4) upper limit of the normal reference range for free lambda light chains

 

ratio of serum free kappa light chains to upper limit of normal =

= (serum concentration kappa light chains) / (upper limit of normal)

 

ratio of serum free lambda light chains to upper limit of normal =

= (serum concentration lambda light chains) / (upper limit of normal)

Ratio kappa light chains

OR of Lymphoma Diagnosis in 2 to 5 Years

1.5 to 1.99

1.9

>= 2.0

3.8

from Figure 1 page 776

 

Ratio lambda light chains

OR of Lymphoma Diagnosis in 2 to 5 Years

1.5 to 1.99

3.4

>= 2.0

8.1

from Figure 1 page 776

 

The risk of lymphoma is higher if the CD4 cell count is >= 100 per µL.

 


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