Yeo et al reported a score for predicting the risk of 3-month mortality following the use of intravenous tissue plasminogen activator (tPA) in an Asian stroke patient. The authors are from National University Health System Singapore, Chang Gung University and affiliated hospitals in Taiwan.
Patient selection: Asian patient status post stroke, following infusion of tissue plasminogen activator (tPA)
Parameters:
(1) age in years
(2) NIHSS in the ER
(3) blood glucose in mg/dL
(4) hyperlipidemia
(5) intracerebral hemorrhage (ICH)
Parameters
Findings
Points
age in years
25
0
30
3
35
5
40
8
45
11
50
14
55
16
60
19
65
22
70
24
75
27
80
30
85
33
90
35
95
38
100
41
NIHSS
0
0
5
12
10
25
15
38
20
50
25
62
30
75
35
87
40
100
blood glucose
50
0
100
4
150
8
200
11
250
15
300
19
350
23
400
27
450
30
500
34
hyperlipidemia
no
15
yes
0
ICH
20
total score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 210
value of X =
= (0.05452 * (score)) - 7.218
probability of 3-month mortality =
= 1 / ( 1 + EXP((-1) *X))
Performance:
• The area under the ROC curve is 0.81 in the derivation and 0.79 in the validation cohorts.
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