Harrison et al reported risk models for invasive Candidiasis in a non-neutropenic adult in the intensive care unit (ICU). One model deals with information available on admission to the ICU. The authors are from multiple institutions in the United Kingdom and participants in the Fungal Infection Risk Evaluation (FIRE) study.
Patient selection: ICU, non-neutropenic adult
Parameters:
(1) history of surgery <= 7 days prior to admission
(2) pancreatitis
(3) number of central venous catheters
(4) number of drains
(5) enteral feeding tube prior to admission
(6) number of samples positive for fungal colonization prior to admission
Parameter
Finding
Beta-Coefficient
history of surgery
none
1.72
elective with no unexpected complications
0
elective with unexpected complications
0.92
emergency or urgent surgery
1.28
pancreatitis
no
0
yes
1.39
number of CVCs
0
0
1
0.40
2
1.43
number of drains
0
0
1 to 3
0.64
4
1.63
enteral feeding tube
no
0
yes
0.42
number of positive samples
0 or 1
0
2
2.06
value of X =
= SUM(points for all 6 parameters) - 7.47
probability of invasive Candidiasis while in ICU =
= 1 / (1 + EXP((-1) * X))
Performance:
• The area under the ROC curve is 0.71 in the derivation and 0.66 in validation cohort.
To read more or access our algorithms and calculators, please log in or register.
