Risk Model of Guglielmi et al for a Patient with Diffuse Large Cell Lymphoma at First Relapse

Description

Guglielmi et al reported a simple risk model for patients with diffuse large cell lymphoma (DLCL) at first relapse. This can help to identify a patient who may benefit from more aggressive management. The authors are from the Italian Intergroup for Lymphoma.

Patient selection: diffuse large lymphoma after initial therapy, both B and T cell

Outcome: risk at first relapse

Parameters:

(1) interval in months between end of first therapy and relapse

(2) serum LDH relative to upper limit of normal (ULN)

(3) Ann Arbor stage at relapse, from I to IV

(4) WHO (ECOG) performance status

Parameter	Finding	Points
Interval	< 12 months	1
	>= 12 months	0
serum LDH	<= ULN	0
	> ULN	1
Ann Arbor stage	I or II	0
	III or IV	1
WHO performance	0 or 1	0
	2 to 4	1

total score =

= SUM(points for all 4 parameters)

Interpretation:

• minimum score: 0

• maximum score: 4

• The higher the score the worse the outcome.

Score	Median Overall Survival
0	> 7 years (> 84 months)
1	42 months
2	21 months
3	6 months
4	4 months

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Risk Model of Guglielmi et al for a Patient with Diffuse Large Cell Lymphoma at First Relapse

Description

Specialty