Giles et al evaluated the outcome of patients with acute myelogenous leukemia who underwent second salvage therapy. This can help separate patients into groups based on short term survival. The authors are from the University of Texas M.D. Anderson Cancer Center in Houston.
Parameters:
(1) duration of first complete remission in months
(2) duration of second complete remission in months
(3) serum total bilirubin concentration
(4) serum albumin concentration
(5) age of the patient in years
(6) percent blasts in the bone marrow
(7) year of second salvage therapy
|
Parameter |
Finding |
Points |
|
duration of first complete remission |
>= 12 months |
0 |
|
|
< 12 months |
1 |
|
duration of second complete remission |
>= 6 months |
0 |
|
|
< 6 months |
1 |
|
serum total bilirubin |
< 1 mg/dL |
0 |
|
|
>= 1 mg/dL |
1 |
|
serum albumin |
>= 3.0 g/dL |
0 |
|
|
< 3.0 g/dL |
1 |
|
age of the patient |
<= 60 years of age |
0 |
|
|
> 60 years of age |
1 |
|
percent blasts in bone marrow |
< 50% |
0 |
|
|
>= 50% |
1 |
|
year of second salvage therapy |
1991 or later |
0 |
|
|
before 1991 |
1 |
where:
• A problem arises in using the score if the time since the second salvage therapy is less than 6 months and the person is still in complete remission.
• Using the year of second salvage therapy may help data analysis but does not make much sense 14 years after the fact (in 2005). This is not included in the spreadsheet.
total number of risk factors =
= SUM(points for all 7 parameters)
Interpretation:
• minimum number of risk factors: 0
• maximum number of risk factors: 7
• The more risk factors present the worse the prognosis.
|
Number of Risk Factors |
Risk Group |
1 Year Survival Rate |
|
0 to 2 |
low |
22% |
|
3 |
intermediate |
6% |
|
4 to 7 |
high |
0% |
Specialty: Hematology Oncology
ICD-10: ,
