Risk Groups of Ellison et al for Childhood Medulloblastoma

Description

Ellison et al identified risk groups for childhood medulloblastoma based on clinical and laboratory features of the tumor. These can help to identify a patient who may benefit from more aggressive management. The authors are from St. Jude Children's Research Hospital, University of Newcastle, and Singleton Hospital in Swansea.

Parameters:

(1) metastases

(2) nuclear immunostaining with beta-catenin

(3) MYC amplification

(4) large cell/anaplastic (LC/A) phenotype

beta-catenin	metastases	MYC amplification	LC/A phenotype	Risk Group
positive	absent	absent	absent	low
negative	absent	absent	absent	standard
NA	positive	NA	positive	worst
NA	NA	positive	positive	worst
NA	all other	all other	all other	high

number of high risk features present =

= (1 if metastases present, else 0) + (1 if MYC amp present, else 0) + (1 if LC/A, else 0)

Number of High Risk Features	Risk Group
2 or 3	worse
1	high
0	low or standard

Risk Group	10 Year Progression Free Survival
low	93%
standard	63%
high	48%
worst	17%

from Figure 2, page 1406.

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Risk Groups of Ellison et al for Childhood Medulloblastoma

Description

Specialty